HDAC inhibitor

HDAC inhibitors are a class of drugs that inhibit the function of Histone Deacetylase (HDAC), an enzyme that plays a key role in the regulation of gene expression. HDAC inhibitors have been studied for their potential use in the treatment of various types of cancer and other diseases.

Mechanism of Action[edit | edit source]

HDAC inhibitors work by blocking the activity of HDAC enzymes, which are involved in the removal of acetyl groups from the histone proteins that make up chromatin. This process, known as deacetylation, is a key part of the regulation of gene expression. By inhibiting deacetylation, HDAC inhibitors can alter the expression of genes and potentially slow or stop the growth of cancer cells.

Types of HDAC Inhibitors[edit | edit source]

There are several types of HDAC inhibitors, including:

Hydroxamic acid-based inhibitors, such as Vorinostat and Panobinostat
Benzamide-based inhibitors, such as Entinostat and Mocetinostat
Cyclic peptide-based inhibitors, such as Romidepsin

Clinical Use[edit | edit source]

HDAC inhibitors have been approved for use in the treatment of certain types of cancer, including cutaneous T-cell lymphoma and multiple myeloma. They are also being studied for potential use in the treatment of other types of cancer, as well as other diseases such as neurodegenerative diseases and inflammatory diseases.

Side Effects[edit | edit source]

Like all drugs, HDAC inhibitors can have side effects. These can include nausea, vomiting, diarrhea, and fatigue. More serious side effects can include low blood cell counts, heart problems, and liver problems.

References[edit | edit source]

HDAC inhibitor Resources
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