KCNE2
KCNE2 is a gene that in humans encodes the potassium voltage-gated channel subfamily E regulatory beta subunit 2. This gene is a member of the KCNE family of genes, which are known to modulate the function of potassium channels.
Function[edit | edit source]
The KCNE2 gene encodes a member of the KCNE family of proteins, which are small proteins that associate with the voltage-gated potassium (Kv) channels and modulate their function. The protein encoded by this gene is known to associate with the KCNQ1 gene product, a protein involved in repolarizing the cardiac action potential, and in the IKs current, which contributes to the cardiac action potential.
Clinical significance[edit | edit source]
Mutations in the KCNE2 gene have been associated with Long QT syndrome, a disorder of the heart's electrical activity that can cause sudden, uncontrollable, and irregular heartbeats (arrhythmias), which may lead to sudden death. It has also been associated with Atrial fibrillation, a common type of abnormal heart rhythm.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
KCNE2 Resources | ||
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Contributors: Prab R. Tumpati, MD