Levine-Crichley syndrome

Levine-Crichley syndrome is a rare neurological disorder characterized by intellectual disability, seizures, and specific physical characteristics. The syndrome was first described by American pediatrician Sol Levine and British neurologist Charles Crichley in the mid-20th century.

Symptoms and Signs

The primary symptoms of Levine-Crichley syndrome include intellectual disability, seizures, and distinctive physical features. The intellectual disability can range from mild to severe, and the seizures can vary in frequency and intensity. Physical characteristics often include a small head (microcephaly), a narrow forehead, deep-set eyes, a small mouth with thin upper lip, and a pointed chin.

Causes

The exact cause of Levine-Crichley syndrome is currently unknown. However, it is believed to be a genetic disorder, possibly caused by a mutation in a gene that is yet to be identified. The syndrome is thought to be inherited in an autosomal recessive manner, which means both parents must carry a copy of the mutated gene for a child to be affected.

Diagnosis

Diagnosis of Levine-Crichley syndrome is based on the presence of characteristic clinical features. Genetic testing may also be used to confirm the diagnosis, although the specific gene associated with the syndrome has not yet been identified.

Treatment

There is currently no cure for Levine-Crichley syndrome. Treatment is symptomatic and supportive, and may include anticonvulsant medication for seizures, special education for intellectual disability, and physical therapy for motor skills development.

Prognosis

The prognosis for individuals with Levine-Crichley syndrome varies depending on the severity of symptoms. With appropriate treatment and support, many individuals with the syndrome can lead fulfilling lives.

See Also

• List of neurological conditions and disorders
• Genetic disorder
• Seizure
• Intellectual disability

NIH genetic and rare disease info

• NIH info on Levine-Crichley syndrome

Levine-Crichley syndrome is a rare disease.

Levine-Crichley syndrome Resources
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