Mac

Minimal alveolar concentration (MAC) is the lowest concentration of the anaesthetic in pulmonary alveoli needed to produce immobility in response to a painful stimulus (surgical incision) in 50% individuals. It is accepted as a valid measure of potency of inhalational GAs because it remains fairly constant for a given species even under varying conditions.

The MAC of a number of GAs shows excellent correlation with their oil/gas partition coefficient. However, this only reflects capacity of the anaesthetic to enter into CNS and attain sufficient concentration in the neuronal membrane, but not the mechanism by which anaesthesia is produced.

Minimal alveolar concentration (MAC) for different inhalation anaesthetics[edit | edit source]

Ether - 1.9
Halothane - 0.75
Enflurane - 1.68
Isoflurane - 1.2
Desflurane - 6.0
Sevoflurane - 2.0
Nitrous oxide - 105

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