NRBC

NRBC or Nucleated Red Blood Cells are immature red blood cells that contain a nucleus. They are typically found in the bone marrow, but can occasionally be found in the peripheral blood. The presence of NRBCs in the peripheral blood is often a sign of severe disease or stress.

Overview

Nucleated red blood cells (NRBCs) are essentially immature red blood cells that still contain a nucleus. Under normal circumstances, the nucleus is expelled from the cell as it matures in the bone marrow, and by the time the cell enters the peripheral bloodstream, it is a mature, non-nucleated red blood cell. However, in certain conditions, NRBCs can be released into the peripheral blood.

Clinical Significance

The presence of NRBCs in the peripheral blood is often a sign of severe disease or stress. This can include conditions such as cancer, sepsis, hemorrhage, or severe anemia. In these cases, the bone marrow may be producing red blood cells at an increased rate, leading to the release of immature cells into the bloodstream.

Detection

NRBCs can be detected through a complete blood count (CBC) with differential. This is a common blood test that measures the number and types of cells in the blood. If NRBCs are present, they will be included in the differential count.

Treatment

Treatment for NRBCs in the peripheral blood involves addressing the underlying condition that is causing the increased production of red blood cells. This may involve treatments such as chemotherapy for cancer, antibiotics for sepsis, or blood transfusion for severe anemia.

See Also

• Red blood cell
• Bone marrow
• Complete blood count

NRBC Resources
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