NT-3

NT-3 or Neurotrophin-3 is a protein that in humans is encoded by the NTF3 gene. Neurotrophin-3 is a neurotrophic factor, in the NGF (Nerve Growth Factor) family, which controls survival and differentiation of mammalian neurons. This protein is closely related to both NGF and BDNF (Brain-Derived Neurotrophic Factor). It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NT-3 is the third neurotrophic factor to be characterized, after NGF and BDNF.

Function

Neurotrophin-3 is a neurotrophic factor that signals predominantly through the TrkC tyrosine kinase receptor, which upon binding leads to the activation of the PI 3-kinase and MAPK pathways. Evidence points to neurotrophic factors being involved in the development of the nervous system and in preventing neuron death.

Clinical significance

Defects in the gene encoding this protein may be associated with congenital hypoplastic anemia.

See also

• Nerve growth factor
• Brain-derived neurotrophic factor
• Neurotrophin-4
• Neurotrophin-5

External links

• GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 2

NT-3 Resources
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