Nuclear receptor co-repressor 2

Nuclear receptor co-repressor 2

File:Nuclear receptor co-repressor 2.jpg

Nuclear receptor co-repressor 2

The Nuclear receptor co-repressor 2 (NCOR2), also known as Silencing Mediator for Retinoid or Thyroid-hormone receptors (SMRT), is a protein that in humans is encoded by the NCOR2 gene. This protein is part of the larger nuclear receptor co-repressors family, which plays a crucial role in gene expression regulation.

Function

NCOR2 is a transcriptional coregulatory protein that contains several nuclear receptor-interacting domains. It is known to play an essential role in the regulation of cellular growth and differentiation, and it is involved in the regulation of circadian rhythms. The protein functions as a part of a complex along with histone deacetylases and other co-repressors to control the transcriptional activity of certain nuclear receptors.

Structure

The NCOR2 protein is composed of several domains, including two repression domains (RD), two receptor interaction domains (RID), and a C-terminal domain. The RDs are responsible for the interaction with histone deacetylases, while the RIDs interact with nuclear receptors. The C-terminal domain is involved in protein-protein interactions.

Clinical Significance

Mutations in the NCOR2 gene have been associated with several types of cancer, including breast cancer and prostate cancer. The protein's role in gene regulation makes it a potential target for therapeutic interventions.

See Also

• Nuclear receptor
• Co-repressor
• Gene expression
• Histone deacetylase