Plasmablast

Plasmablasts are a type of B cell that produce antibody in response to an immune response. They are derived from germinal center B cells following somatic hypermutation and class switch recombination. Plasmablasts are typically short-lived and differentiate into plasma cells, which are long-lived and continue to produce antibody.

Function

Plasmablasts are responsible for the production of antibody during an immune response. They are derived from germinal center B cells following somatic hypermutation and class switch recombination, processes that increase the affinity and specificity of the antibody for its target antigen.

Differentiation

Following activation by an antigen, B cells enter the germinal center where they undergo somatic hypermutation and class switch recombination. The B cells that have successfully undergone these processes differentiate into plasmablasts. Plasmablasts are typically short-lived and differentiate into plasma cells, which are long-lived and continue to produce antibody.

Role in disease

Plasmablasts have been implicated in several diseases, including autoimmune diseases and cancer. In autoimmune diseases, plasmablasts may produce autoantibodies that target the body's own tissues. In cancer, plasmablasts may contribute to tumor growth and progression.

See also

• B cell
• Germinal center
• Somatic hypermutation
• Class switch recombination
• Plasma cell

Plasmablast Resources
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