RpoF

RpoF is a sigma factor that is part of the RNA polymerase complex in bacteria. It is also known as Sigma28 and is responsible for the initiation of transcription of specific genes.

Function

RpoF is a sigma factor that is part of the RNA polymerase complex in bacteria. It is responsible for the initiation of transcription of specific genes. The sigma factor is a protein needed only for initiation of RNA synthesis. In the Escherichia coli bacterium, RpoF is the sigma factor that recognizes and binds to the promoter region of flagellar and chemotaxis genes, initiating their transcription.

Structure

RpoF is a small protein with a molecular weight of approximately 22 kDa. It is composed of four domains, with the 2nd and 4th domains involved in promoter recognition and binding. The 1st and 3rd domains are involved in interactions with the core RNA polymerase.

Role in Bacterial Motility

RpoF plays a crucial role in bacterial motility by controlling the expression of flagellar and chemotaxis genes. In the absence of RpoF, bacteria are unable to move or respond to chemical gradients in their environment.

See Also

• Sigma factor
• RNA polymerase
• Transcription (genetics)
• Escherichia coli

References

RpoF Resources
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