Selective androgen receptor degrader

A selective androgen receptor degrader or downregulator (SARD) is a type of drug which interacts with the androgen receptor (AR) such that it causes the AR to be degraded and thus downregulated.^[1] They are under investigation for the treatment of prostate cancer and other androgen-dependent conditions.^[1]

As of 2017, dimethylcurcumin (ASC-J9), a SARD, is under development for the treatment of acne vulgaris.^[2]

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