Therapeutic Targets Database

TTD logo

Therapeutic Targets Database (TTD) is a comprehensive resource that provides information on the known and explored therapeutic targets, the targeted disease conditions, the pathway information, and the corresponding drugs directed at each of these targets. The database is designed to facilitate the development of novel therapeutic agents by providing detailed information on the molecular targets of approved, clinical trial, and experimental drugs.

Overview

The Therapeutic Targets Database was established to provide a centralized repository of information on therapeutic targets. It includes data on the biological entities (such as proteins, genes, and RNA) that are targeted by drugs to treat various diseases. The database is widely used by researchers in the fields of pharmacology, biochemistry, and molecular biology.

Content

The TTD includes several key types of information:

• **Therapeutic Targets**: Detailed information on the molecular targets, including their biological functions, associated diseases, and the drugs that interact with them.
• **Disease Conditions**: Information on the diseases associated with each therapeutic target.
• **Pathway Information**: Data on the biological pathways involving the therapeutic targets.
• **Drug Information**: Details on the drugs that target specific molecules, including their mechanisms of action, clinical trial status, and approval status.

Applications

The TTD is used for various applications in drug discovery and development:

• **Target Identification**: Researchers use the database to identify potential new targets for drug development.
• **Drug Repositioning**: The database helps in finding new therapeutic uses for existing drugs.
• **Pathway Analysis**: Scientists use the pathway information to understand the biological processes involved in disease and to identify potential intervention points.

Access and Usage

The Therapeutic Targets Database is accessible to the public and can be used by researchers worldwide. It is frequently updated to include the latest information on therapeutic targets and drugs.

See Also

• DrugBank
• PharmGKB
• PubChem
• ChEMBL
• KEGG