WDR68

WDR68

WDR68 is a gene that encodes a protein called WD repeat domain 68. This protein is found in humans and is involved in various cellular processes. The WDR68 gene is located on chromosome 1 and is conserved across different species.

Function

The WD repeat domain 68 protein is a member of the WD repeat family, which is characterized by the presence of multiple copies of a conserved sequence motif called the WD repeat. These repeats are involved in protein-protein interactions and play a crucial role in various cellular processes, including signal transduction, cell cycle regulation, and protein folding.

The exact function of WDR68 is not fully understood, but studies have suggested its involvement in several cellular processes. It has been shown to interact with other proteins involved in RNA processing and splicing, suggesting a role in gene expression regulation. Additionally, WDR68 has been implicated in DNA repair and maintenance of genomic stability.

Clinical Significance

Mutations in the WDR68 gene have been associated with certain genetic disorders. For example, mutations in WDR68 have been found in individuals with intellectual disability and developmental delay. These mutations may disrupt the normal function of the protein, leading to impaired cellular processes and neurological abnormalities.

Furthermore, studies have also linked WDR68 to cancer development. Abnormal expression of WDR68 has been observed in various types of cancer, including breast, lung, and colorectal cancer. It is believed that dysregulation of WDR68 may contribute to tumor growth and progression, although the exact mechanisms are still under investigation.

References

<references>

See Also

• Gene
• Protein
• Chromosome
• RNA processing
• Splicing
• Intellectual disability
• Developmental delay
• Cancer
• Breast cancer
• Lung cancer
• Colorectal cancer

External Links

• WDR68 Gene - NCBI
• WDR68 Protein - UniProt