Formyl peptide receptor 2
Formyl peptide receptor 2 (FPR2), also known as ALX or FPRL1, is a protein that in humans is encoded by the FPR2 gene. This protein is a member of the G protein-coupled receptor family, and plays a crucial role in the immune system and inflammation response.
Structure[edit | edit source]
The FPR2 protein is a cell surface receptor that is predominantly expressed in immune cells such as neutrophils, monocytes, and macrophages. It is a seven-transmembrane domain receptor, which is a characteristic feature of G protein-coupled receptors.
Function[edit | edit source]
FPR2 is involved in the regulation of several key functions of the immune system. It is activated by a variety of ligands, including lipoxin A4 and serum amyloid A. Upon activation, FPR2 triggers a series of intracellular signaling pathways that lead to various immune responses, such as chemotaxis, phagocytosis, and the production of reactive oxygen species.
Clinical significance[edit | edit source]
Alterations in the function or expression of FPR2 have been implicated in a variety of diseases, including chronic obstructive pulmonary disease, asthma, rheumatoid arthritis, and Alzheimer's disease. Therefore, FPR2 is considered a potential therapeutic target for these conditions.
Research[edit | edit source]
Research on FPR2 is ongoing, with studies focusing on understanding its role in the immune system and its potential as a therapeutic target. Some studies are investigating the use of FPR2 agonists and antagonists in the treatment of inflammatory diseases.
See also[edit | edit source]
References[edit | edit source]
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Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD