Somatostatin receptor 3
Somatostatin receptor 3 (SSTR3) is a protein that in humans is encoded by the SSTR3 gene. It is one of the five G protein-coupled receptors for somatostatin, a hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors.
Structure[edit | edit source]
The SSTR3 gene is located on the short (p) arm of chromosome 22 at position 13.3. The protein encoded by this gene is a multi-pass membrane protein that functions as a receptor for somatostatin-14 and somatostatin-28. It is one of the five somatostatin receptors, which are members of the G protein-coupled receptor family.
Function[edit | edit source]
SSTR3 is involved in the inhibition of the release of insulin, glucagon and growth hormone. It also plays a role in cell proliferation, apoptosis, and neuronal activities. The receptor is available in many tissues including the brain, pancreas, and gastrointestinal tract.
Clinical significance[edit | edit source]
Mutations in the SSTR3 gene have been associated with diseases such as acromegaly, a disorder characterized by excessive growth due to the overproduction of growth hormone. In addition, SSTR3 has been implicated in the pathogenesis of neuroendocrine tumors.
See also[edit | edit source]
References[edit | edit source]
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