P2RY13
P2RY13 is a gene that encodes the protein P2Y13 receptor in humans. This protein is a member of the G protein-coupled receptor family, which are integral membrane proteins that respond to various stimuli like light, peptides, lipids, sugars, and proteins. The P2Y13 receptor is activated by adenosine diphosphate (ADP), a molecule involved in energy transfer in cells.
Function[edit | edit source]
The P2Y13 receptor is involved in several biological processes. It plays a crucial role in the regulation of immune responses and inflammation. The receptor is also involved in the regulation of cholesterol homeostasis. When activated, it stimulates the release of apolipoprotein A-I, a protein that removes cholesterol from tissues and transports it to the liver for excretion.
Clinical significance[edit | edit source]
Mutations in the P2RY13 gene have been associated with various diseases. For example, a study found that a variant of the P2RY13 gene was associated with an increased risk of coronary artery disease. Another study suggested that the P2Y13 receptor could be a potential therapeutic target for atherosclerosis, a disease characterized by the buildup of fats, cholesterol, and other substances in and on the artery walls.
See also[edit | edit source]
- P2Y receptor
- G protein-coupled receptor
- Adenosine diphosphate
- Apolipoprotein A-I
- Coronary artery disease
- Atherosclerosis
References[edit | edit source]
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