4-DAMP

4-DAMP (1,1-dimethyl-4-diphenylacetoxypiperidinium iodide) is a selective muscarinic M3 receptor antagonist. It is often used in scientific research to understand the function and role of M3 receptors in the body.

Chemistry

4-DAMP is a quaternary ammonium compound. It is a derivative of piperidine, a heterocyclic organic compound. The compound is iodinated, meaning it contains an iodine atom. The presence of iodine allows for the compound to be used in radioligand binding studies.

Pharmacology

In pharmacology, 4-DAMP is known for its selective antagonism of the M3 muscarinic receptors. Muscarinic receptors are a type of acetylcholine receptor. They are metabotropic and are found in various parts of the body including the central nervous system and peripheral tissues. The M3 subtype is primarily found in smooth muscle and glandular tissue.

4-DAMP's antagonism of the M3 receptor can lead to various physiological effects. For example, it can cause bronchodilation (widening of the airways in the lungs) and inhibit glandular secretion. This makes it a useful tool in research related to respiratory and glandular diseases.

Use in Research

4-DAMP is primarily used in research settings. It is often used in radioligand binding studies to investigate the distribution and function of M3 receptors. It can also be used in functional studies to understand the physiological effects of M3 receptor activation and inhibition.

Safety

As with any chemical compound, safety precautions should be taken when handling 4-DAMP. It should be handled in a well-ventilated area and protective clothing should be worn to prevent skin and eye contact.

See Also

• Muscarinic antagonist
• Muscarinic receptors
• Piperidine