4-hydroperoxycyclophosphamide

4-Hydroperoxycyclophosphamide is an oncological drug that is a derivative of cyclophosphamide. It is used in the treatment of various types of cancer, including leukemia, lymphoma, and solid tumors.

Chemistry

4-Hydroperoxycyclophosphamide is a prodrug that is converted in the body to the active form, phosphoramide mustard. This conversion is mediated by cytochrome P450 enzymes in the liver. The drug also produces a byproduct, acrolein, which is responsible for some of the drug's side effects.

Mechanism of Action

The active form of 4-hydroperoxycyclophosphamide, phosphoramide mustard, works by cross-linking DNA, which prevents the DNA from being properly copied during cell division. This leads to cell death and prevents the growth of cancer cells.

Side Effects

The most common side effects of 4-hydroperoxycyclophosphamide include nausea, vomiting, and hair loss. The drug can also cause more serious side effects, such as bone marrow suppression, which can lead to an increased risk of infection, anemia, and bleeding. The byproduct acrolein can cause bladder damage, which can be prevented by co-administration of mesna.

Clinical Use

4-Hydroperoxycyclophosphamide is used in the treatment of a variety of cancers. It is often used in combination with other drugs as part of a chemotherapy regimen. The drug is also used in stem cell transplantation to prepare the patient's body for the transplant.

See Also

• Cyclophosphamide
• Chemotherapy
• Oncology

References

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