5-APDB

3-desoxy-MDA

5-APDB (5-(2-Aminopropyl)benzofuran) is a psychoactive drug and research chemical that belongs to the substituted benzofuran class. It is closely related to compounds such as 5-MAPB and 6-APDB, sharing a similar chemical structure and effects. 5-APDB is known for its entactogenic, psychedelic, and stimulant properties, which are primarily attributed to its action as a serotonin, dopamine, and norepinephrine reuptake inhibitor or releaser. However, the exact pharmacological mechanisms of 5-APDB remain less understood compared to more extensively studied analogs.

Chemistry

5-APDB is a benzofuran derivative, which is a class of compounds characterized by a benzene ring fused to a furan ring. The chemical formula for 5-APDB is C_11H_15NO_2, indicating it contains a chain of two carbon atoms extending from the 5-position of the benzofuran ring, ending in an amino group. This structure is similar to that of other entactogens in the amphetamine and phenethylamine classes, which explains its similar pharmacological effects.

Pharmacology

The pharmacological action of 5-APDB is primarily as a serotonin releaser, with additional actions on dopamine and norepinephrine systems. This action is responsible for its entactogenic effects, promoting feelings of empathy, emotional openness, and well-being. However, due to its psychoactive properties and potential for abuse, its use is mainly confined to research settings and it is not approved for medical use.

Effects

Users of 5-APDB report a range of subjective effects, including enhanced mood, increased empathy and sociability, mild hallucinations, and altered perception of time. The effects are often compared to those of MDMA, though typically reported to be less intense and more manageable. Side effects can include anxiety, nausea, increased heart rate, and insomnia, similar to other stimulants and entactogens.

Legal Status

The legal status of 5-APDB varies by country, with some jurisdictions classifying it as a controlled substance due to its potential for abuse and lack of medical use. In countries where it is not explicitly controlled, it may still fall under analogue laws, making its sale and possession for human consumption illegal.

Research

Research on 5-APDB is limited, with most studies focusing on its chemistry, pharmacology, and toxicology in the context of its potential for abuse. There is interest in the therapeutic potential of benzofurans as entactogens, but further research is needed to understand their safety, efficacy, and potential medical applications.

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