ADCY10

ADCY10 (Adenylate Cyclase 10), also known as soluble adenylate cyclase (sAC), is an enzyme that in humans is encoded by the ADCY10 gene. It is a member of the adenylate cyclase family, which is a group of enzymes that convert ATP (adenosine triphosphate) into cyclic AMP (cAMP) and pyrophosphate.

Function

ADCY10 is a non-canonical, soluble form of adenylate cyclase. Unlike the traditional, transmembrane adenylate cyclases, ADCY10 is not regulated by G-protein coupled receptors. Instead, it is directly stimulated by bicarbonate ions. The cAMP produced by ADCY10 is involved in various physiological processes, including sperm maturation and the regulation of cilia and flagella.

Clinical Significance

Mutations in the ADCY10 gene have been associated with various medical conditions. For example, a mutation in this gene has been linked to asthenozoospermia, a condition characterized by reduced sperm motility. This is due to the role of ADCY10 in sperm maturation and motility.

Research

Research into ADCY10 is ongoing, with studies investigating its role in various physiological processes and potential as a therapeutic target. For example, it has been suggested that inhibiting ADCY10 could be a potential treatment for cystic fibrosis, due to its role in regulating cilia and flagella.

See Also

• Adenylate cyclase
• Cyclic AMP
• G-protein coupled receptors
• Asthenozoospermia
• Cystic fibrosis

References

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