Archain 1

Archain 1 is a protein that in humans is encoded by the ARCN1 gene. It is a component of the coatomer protein complex, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the endoplasmic reticulum, via the Golgi up to the trans Golgi network.

Function

Archain 1 is involved in the transport of proteins from the endoplic reticulum to the Golgi apparatus and from the Golgi apparatus to the cell membrane. It is a subunit of the coatomer protein complex, which is responsible for the formation of vesicles that transport these proteins.

Structure

The ARCN1 gene provides instructions for making the Archain 1 protein. This protein is a part of the coatomer protein complex, which is made up of seven different proteins. The Archain 1 protein interacts with several other proteins in the complex to carry out its function.

Clinical significance

Mutations in the ARCN1 gene can lead to a variety of health problems. For example, they can cause congenital disorders of glycosylation, which are genetic disorders that affect the body's ability to attach sugar molecules to proteins (glycosylation). These disorders can lead to a wide variety of health problems, including developmental delay, intellectual disability, and problems with the liver and other organs.

See also

• Coatomer protein complex
• Endoplasmic reticulum
• Golgi apparatus
• Cell membrane
• Congenital disorders of glycosylation

References

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