Büchner–Curtius–Schlotterbeck reaction
The Büchner–Curtius–Schlotterbeck reaction is a chemical reaction that involves the conversion of ketones or aldehydes into α,β-unsaturated carbonyl compounds. This reaction is named after the chemists Eduard Büchner, Theodor Curtius, and Friedrich Schlotterbeck, who contributed to its development.
Mechanism[edit | edit source]
The Büchner–Curtius–Schlotterbeck reaction proceeds through a series of steps that typically involve the formation of an intermediate hydrazone or oxime, followed by a rearrangement and elimination process. The general mechanism can be summarized as follows:
- Formation of a hydrazone or oxime from the ketone or aldehyde.
- Rearrangement of the hydrazone or oxime to form an intermediate diazo compound.
- Elimination of nitrogen gas (N₂) to yield the α,β-unsaturated carbonyl compound.
Applications[edit | edit source]
This reaction is particularly useful in organic synthesis for the preparation of α,β-unsaturated carbonyl compounds, which are valuable intermediates in the synthesis of various pharmaceuticals, natural products, and fine chemicals.
Related Reactions[edit | edit source]
The Büchner–Curtius–Schlotterbeck reaction is related to several other name reactions in organic chemistry, including:
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
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