Flubendazole
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Flubendazole is a benzimidazole derivative used as an anthelmintic. It is primarily used to treat parasitic worm infections in both humans and animals.
Chemistry[edit | edit source]
Flubendazole is a white to off-white powder that is slightly soluble in water and freely soluble in dimethyl sulfoxide (DMSO) and dimethylformamide. The chemical name for flubendazole is methyl [5-(2-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate. Its molecular formula is C_16H_12FN_3O_3.
Pharmacology[edit | edit source]
Flubendazole works by inhibiting the microtubule function in the parasite's cells, leading to the death of the parasite. It is effective against a wide range of parasites, including nematodes, cestodes, and trematodes.
Medical uses[edit | edit source]
Flubendazole is used to treat a variety of parasitic worm infections, including ascariasis, hookworm infections, trichuriasis, strongyloidiasis, and enterobiasis. It is also used in veterinary medicine to treat a range of animal parasites.
Side effects[edit | edit source]
Common side effects of flubendazole include nausea, vomiting, diarrhea, and abdominal pain. In rare cases, it can cause more serious side effects such as granulocytopenia, thrombocytopenia, and anemia.
History[edit | edit source]
Flubendazole was first synthesized in the 1970s by Janssen Pharmaceutica, a Belgian pharmaceutical company. It has since been used worldwide to treat parasitic worm infections in both humans and animals.
See also[edit | edit source]
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