CD200R1

CD200R1 is a protein that in humans is encoded by the CD200R1 gene. It is also known as OX2R, MOX2R, or MRC. This protein is a member of the immunoglobulin superfamily and is a receptor for the CD200 molecule.

Function

The CD200R1 protein plays a role in the regulation of immune responses. It is expressed on the surface of various immune cells, including T cells, B cells, monocytes, and macrophages. When CD200 binds to CD200R1, it delivers an inhibitory signal that suppresses the activity of these immune cells. This interaction is thought to help prevent excessive or inappropriate immune responses, such as those that can lead to autoimmune diseases or chronic inflammation.

Clinical significance

Alterations in the function or expression of CD200R1 have been associated with several diseases. For example, reduced expression of CD200R1 has been observed in patients with multiple sclerosis, suggesting that this protein may play a role in the pathogenesis of this disease. Similarly, increased expression of CD200R1 has been reported in certain types of cancer, including melanoma and leukemia, where it may contribute to immune evasion by tumor cells.

Research

Research is ongoing to better understand the role of CD200R1 in health and disease, and to explore its potential as a therapeutic target. For example, drugs that block the interaction between CD200 and CD200R1 are being developed as potential treatments for autoimmune diseases and cancer.

See also

• CD200
• Immunoglobulin superfamily
• Immune response
• Autoimmune diseases
• Chronic inflammation

References

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