CD45RA
CD45RA is a protein that in humans is encoded by the PTPRC gene. It is a member of the protein tyrosine phosphatase (PTP) family, which is known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
Function[edit | edit source]
CD45RA is an isoform of the CD45 family. The CD45 family is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein tyrosine phosphatases are present in all hematopoietic cells except erythrocytes and platelets.
Clinical significance[edit | edit source]
CD45RA is expressed on naive T cells and is downregulated upon their activation. Its expression is commonly used as a marker to distinguish naive T cells from memory T cells in studies of the immune system. In addition, alterations in CD45RA expression have been associated with various diseases, including autoimmune diseases, cancer, and infectious diseases.
See also[edit | edit source]
References[edit | edit source]
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