CMKLR1

CMKLR1 (Chemokine-like receptor 1) is a protein that in humans is encoded by the CMKLR1 gene. It is also known as ChemR23, DEZ, or ChemerinR. CMKLR1 is a member of the G protein-coupled receptor family, and it has been implicated in various biological processes, including inflammation, adipogenesis, and cardiovascular disease.

Function[edit | edit source]

CMKLR1 is a receptor for the chemoattractant protein Chemerin, and it mediates its effects through G protein-coupled signaling pathways. The activation of CMKLR1 by Chemerin can lead to intracellular calcium release and the activation of the phosphatidylinositol 3-kinase pathway.

In addition to its role in inflammation, CMKLR1 has been shown to play a role in the regulation of adipogenesis. It is expressed in adipose tissue, and its activation can promote the differentiation of pre-adipocytes into mature adipocytes.

Clinical significance[edit | edit source]

Alterations in the function or expression of CMKLR1 have been associated with various diseases. For example, increased expression of CMKLR1 has been observed in atherosclerotic plaques, suggesting a role in the development of cardiovascular disease. In addition, mutations in the CMKLR1 gene have been linked to obesity and metabolic syndrome.

References[edit | edit source]

External links[edit | edit source]

CMKLR1 at the National Center for Biotechnology Information

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CMKLR1 Resources
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