CYP4B1

CYP4B1 is a gene that encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene.

Function

CYP4B1 is part of the cytochrome P450 family of enzymes. These enzymes are responsible for oxidizing various substrates in the metabolic process, including drugs, fatty acids, and steroids. Specifically, CYP4B1 is involved in the metabolism of xenobiotics, or foreign substances in the body. This includes certain anti-cancer drugs such as cyclophosphamide and ifosphamide.

Clinical significance

Alterations in the CYP4B1 gene have been associated with various health conditions. For example, a decrease in CYP4B1 activity has been observed in patients with cancer, potentially affecting the efficacy of certain anti-cancer drugs. Additionally, polymorphisms in this gene may influence an individual's susceptibility to lung cancer.

See also

• Cytochrome P450
• Xenobiotic metabolism
• Cyclophosphamide
• Ifosphamide

References

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