Dinitrochlorobenzene

From WikiMD's Food, Medicine & Wellness Encyclopedia

Dinitrochlorobenzene (DNCB) is a type of chemical compound that belongs to the group of organic compounds known as aromatic compounds. It is a yellow, crystalline solid that is not soluble in water but is soluble in ethanol and ether.

Chemical Structure[edit | edit source]

Dinitrochlorobenzene has the chemical formula C6H3Cl(NO2)2. It consists of a benzene ring substituted with two nitro groups and one chlorine atom. The nitro groups are electron-withdrawing groups, which makes the benzene ring less reactive towards electrophilic aromatic substitution reactions.

Synthesis[edit | edit source]

Dinitrochlorobenzene can be synthesized by the nitration of chlorobenzene using a mixture of nitric acid and sulfuric acid. The reaction proceeds via an electrophilic aromatic substitution mechanism.

Uses[edit | edit source]

Dinitrochlorobenzene is used in the synthesis of dyes, pharmaceuticals, and other organic compounds. It is also used in the manufacture of explosives. In medicine, it has been used as a topical immunomodulator in the treatment of warts and molluscum contagiosum.

Health Effects[edit | edit source]

Exposure to dinitrochlorobenzene can cause skin irritation, eye irritation, and respiratory irritation. It is also a potential carcinogen.

Safety[edit | edit source]

Dinitrochlorobenzene should be handled with care. It should be stored in a cool, dry place away from heat and open flames. It should not be ingested or come into contact with the skin or eyes.


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Contributors: Prab R. Tumpati, MD