Dissolution
Dissolution is a process in which a solid substance solubilizes in a certain solvent to yield a solution. This process is widely used in the pharmaceutical industry, particularly in the development of drugs and medications.
Overview[edit | edit source]
Dissolution is a critical process in the pharmaceutical industry as it can affect the bioavailability of a drug. The rate of dissolution of a substance is determined by the Noyes-Whitney equation, which takes into account the surface area of the solid, the diffusion coefficient of the solvent, and the concentration of the solid in the solvent.
Dissolution Testing[edit | edit source]
Dissolution testing is a standard method used in the pharmaceutical industry to determine the dissolution rate of a drug. This test is important in the development of drugs as it can predict the in vivo (in the body) dissolution and absorption of the drug.
Factors Affecting Dissolution[edit | edit source]
Several factors can affect the dissolution rate of a drug. These include the particle size of the drug, the temperature of the solvent, the pH of the solvent, and the presence of surfactants.
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD