Dystrobrevin beta

Dystrobrevin beta (DTNB) is a protein that in humans is encoded by the DTNB gene. It is a member of the dystrophin family, which is involved in a variety of cellular processes.

Function

Dystrobrevin beta is a component of the dystrophin-associated protein complex (DAPC), which plays a crucial role in maintaining the integrity of muscle fibers. The DAPC acts as a bridge between the cytoskeleton and the extracellular matrix, providing structural support to the muscle fibers and protecting them from damage during muscle contraction and relaxation.

Clinical significance

Mutations in the DTNB gene have been associated with a variety of neuromuscular disorders, including Duchenne muscular dystrophy and Becker muscular dystrophy. These disorders are characterized by progressive muscle weakness and wasting, and are often fatal.

Research

Research into dystrobrevin beta and its role in neuromuscular disorders is ongoing. Understanding the function of this protein and how mutations in the DTNB gene lead to disease could potentially lead to new treatments for these disorders.

See also

• Dystrobrevin alpha
• Dystrophin
• Dystrophin-associated protein complex
• Duchenne muscular dystrophy
• Becker muscular dystrophy

References

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