E4F1

E4F1 is a protein that in humans is encoded by the E4F1 gene. The E4F1 protein is a key regulator of cell cycle progression and apoptosis, and plays a significant role in tumor suppression.

Function

The E4F1 protein is a transcription factor involved in the regulation of cell proliferation. It is also implicated in the control of the G1/S transition of the cell cycle. The E4F1 protein has been shown to interact with p53, a protein known for its critical role in preventing cancer.

Clinical significance

Alterations in the E4F1 gene have been associated with various types of cancer, including breast cancer and lung cancer. The E4F1 protein is considered a potential target for cancer therapy due to its role in cell cycle regulation and apoptosis.

Research

Research on the E4F1 protein has focused on its role in cell cycle regulation and its potential as a target for cancer therapy. Studies have shown that E4F1 is essential for embryonic development and that its absence can lead to embryonic lethality.

See also

• Cell cycle
• Apoptosis
• Tumor suppressor
• p53

External links

• GeneCards: E4F1

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