EIF3CL

EIF3CL or Eukaryotic Translation Initiation Factor 3 Subunit C Like is a protein that in humans is encoded by the EIF3CL gene. The protein encoded by this gene is a component of the eukaryotic translation initiation factor 3 (eIF3) complex, which is required for several steps in the initiation of protein synthesis.

Function

The eIF3 complex associates with the 40S ribosome and facilitates the recruitment of mRNA, tRNA, and ribosomal subunits. In addition to its role in protein synthesis, the eIF3 complex is also thought to play a role in cell cycle progression, cell proliferation, and cell differentiation. The EIF3CL protein specifically is thought to be involved in the regulation of cell growth and cell division.

Structure

The EIF3CL protein is a subunit of the eIF3 complex. It is composed of multiple protein domains, including a PCI domain and an RRM domain. The PCI domain is involved in protein-protein interactions and is necessary for the assembly of the eIF3 complex. The RRM domain is involved in RNA binding and is necessary for the function of the eIF3 complex in protein synthesis.

Clinical Significance

Alterations in the expression of the EIF3CL gene have been associated with several types of cancer, including breast cancer, lung cancer, and colorectal cancer. In these cancers, overexpression of the EIF3CL gene has been associated with increased cell proliferation and poor prognosis. However, the exact role of EIF3CL in cancer development and progression is still under investigation.

See Also

• Eukaryotic translation initiation factor 3
• Protein synthesis
• Cell cycle
• Cell proliferation
• Cell differentiation

References

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