Eoxin

Eoxin is a group of prostaglandin-like compounds, which are produced by the eosinophil cells in the human body. These compounds are formed from arachidonic acid through the lipoxygenase pathway. Eoxins are known to play a significant role in the pathophysiology of asthma and other inflammatory diseases.

Structure and Synthesis

Eoxins are derived from arachidonic acid, a polyunsaturated fatty acid. The synthesis of eoxins involves the action of the enzyme 15-lipoxygenase on arachidonic acid, leading to the formation of 15-hydroperoxyeicosatetraenoic acid (15-HPETE). This compound is then converted into eoxin A4 (EXA4) by the action of leukotriene C4 synthase. EXA4 can be further converted into eoxin B4, C4, and D4.

Function

Eoxins are potent mediators of inflammation. They are involved in the recruitment and activation of eosinophils, which are a type of white blood cell that plays a key role in the immune response to parasitic infections and in allergic reactions. Eoxins have been found to be elevated in the airways of individuals with asthma, suggesting a role in the pathogenesis of this disease.

Clinical Significance

The role of eoxins in inflammatory diseases has led to interest in their potential as therapeutic targets. Inhibitors of the lipoxygenase pathway, which blocks the synthesis of eoxins, are being investigated for the treatment of asthma and other inflammatory conditions.

See Also

• Leukotriene
• Prostaglandin
• Arachidonic acid
• Lipoxygenase
• Eosinophil

References

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