FABP5

Protein FABP5 PDB 1b56

FABP5

Fatty Acid Binding Protein 5 (FABP5) is a protein that in humans is encoded by the FABP5 gene. FABP5 is a member of the fatty acid-binding protein (FABP) family, which is involved in the intracellular transport of fatty acids. It is primarily expressed in tissues such as the skin, adipose tissue, and mammary glands.

Structure

FABP5 consists of approximately 132 amino acids and has a molecular weight of around 15 kDa. It contains two alpha-helices that form a binding pocket for fatty acids. The protein is predominantly cytoplasmic but can also be found in the nucleus.

Function

FABP5 plays a crucial role in lipid metabolism by facilitating the uptake, transport, and utilization of long-chain fatty acids. It is involved in regulating various cellular processes, including lipid signaling, inflammation, and differentiation. FABP5 has been implicated in skin barrier function, adipocyte development, and breast cancer progression.

Clinical Significance

Aberrant expression of FABP5 has been associated with various diseases, including metabolic disorders, inflammatory conditions, and cancer. In cancer, FABP5 has been linked to tumor growth, metastasis, and resistance to therapy. Targeting FABP5 may offer potential therapeutic opportunities for these conditions.

Interactions

FABP5 interacts with a variety of proteins involved in lipid metabolism, signaling pathways, and gene regulation. These interactions modulate the functions of FABP5 and contribute to its diverse roles in cellular processes.