FGF16
FGF16 or Fibroblast Growth Factor 16 is a protein that in humans is encoded by the FGF16 gene. It is a member of the fibroblast growth factor (FGF) family, which is involved in a variety of biological processes.
Function[edit | edit source]
FGF16 is a secreted protein that binds to FGFR 1c, FGFR 2c, FGFR 3c, and FGFR 4. It is involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. FGF16 has been shown to promote cardiac proliferation and repair.
Structure[edit | edit source]
The FGF16 protein is composed of 207 amino acids and has a molecular weight of approximately 23.3 kDa. It contains a signal peptide at the N-terminus, which is cleaved off during maturation. The mature protein has a core region that is highly conserved among all FGF family members.
Clinical Significance[edit | edit source]
Mutations in the FGF16 gene have been associated with a variety of diseases, including heart disease and cancer. In particular, overexpression of FGF16 has been observed in several types of cancer, suggesting that it may play a role in tumor progression.
Research[edit | edit source]
Research on FGF16 has focused on its role in cardiac development and repair, as well as its potential as a therapeutic target in cancer. Studies have shown that FGF16 can promote cardiac cell proliferation and improve cardiac function following injury.
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD