FHL5

FHL5 (Four and a half LIM domains 5) is a protein that in humans is encoded by the FHL5 gene. This protein is a member of the four and a half LIM domains (FHL) protein family, which are characterized by the presence of four and a half LIM domains. LIM domains are highly conserved cysteine-rich structures that are involved in protein-protein interactions.

Function

FHL5 is known to interact with androgen receptor (AR), a type of nuclear receptor that is activated by binding of either of the androgenic hormones, testosterone, or dihydrotestosterone. The FHL5 protein can repress the transactivation activity of AR through its LIM domains. This suggests that FHL5 may participate in the regulation of gene expression in the nucleus by modulating the functional activities of AR.

Clinical significance

Mutations in the FHL5 gene have been associated with idiopathic dilated cardiomyopathy (IDC). IDC is a disorder of the heart muscle, characterized by dilatation and impaired contraction of the left ventricle or both ventricles. It may lead to heart failure, arrhythmia, thromboembolism, and sudden cardiac death.

See also

• Four and a half LIM domains
• Androgen receptor
• Idiopathic dilated cardiomyopathy

References

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