FKBPL

FKBPL (FK506 Binding Protein Like) is a protein that in humans is encoded by the FKBPL gene. This protein is a member of the immunophilin protein family, which play a role in immunity and cellular signaling.

Function

FKBPL has been shown to interact with Dynein, a motor protein involved in cell division and intracellular transport. The FKBPL-Dynein interaction is thought to be important for the proper functioning of the cell cycle.

FKBPL is also involved in the regulation of heat shock proteins, which are crucial for protein folding and protection against stress. In particular, FKBPL has been shown to regulate the activity of Hsp90, a heat shock protein that plays a key role in the stability and function of several client proteins.

Clinical significance

Alterations in the FKBPL gene have been associated with various types of cancer, including breast cancer and prostate cancer. FKBPL is thought to act as a tumor suppressor, and its downregulation has been linked to increased tumor growth and progression.

In addition, FKBPL has been implicated in the response to chemotherapy. Studies have shown that high levels of FKBPL are associated with a better response to chemotherapy, suggesting that this protein could be used as a potential biomarker for treatment response.

Research

Research is ongoing to further understand the role of FKBPL in cancer and to explore its potential as a therapeutic target. Several studies are investigating the use of FKBPL-based peptides as a novel cancer treatment.

See also

• FK506 binding protein
• Dynein
• Heat shock protein
• Tumor suppressor

References

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