GHB overdose

Gamma-Hydroxybutyric acid (GHB) overdose is a medical condition resulting from the excessive consumption of GHB, a central nervous system depressant that is used both as a recreational drug and as a treatment for certain medical conditions such as narcolepsy. GHB overdose can lead to severe and potentially life-threatening symptoms due to its depressive effects on the central nervous system.

Signs and Symptoms

The signs and symptoms of GHB overdose can vary depending on the amount ingested and the individual's sensitivity to the drug. Common symptoms include:

• Nausea and vomiting
• Dizziness
• Respiratory depression
• Loss of consciousness
• Seizures
• Coma

In severe cases, GHB overdose can lead to respiratory failure, cardiac arrest, and death.

Causes

GHB overdose occurs when an individual ingests a dose of GHB that exceeds the body's ability to metabolize and eliminate the drug safely. Factors that can increase the risk of overdose include:

• Taking higher doses than tolerated
• Combining GHB with other central nervous system depressants such as Alcohol or Benzodiazepines
• Variability in the concentration of GHB in illicit preparations

Treatment

Treatment for GHB overdose focuses on supportive care and managing the symptoms. There is no specific antidote for GHB overdose. Treatment may include:

• Monitoring of Vital signs
• Supportive care for respiratory and cardiovascular functions
• Administration of Intravenous fluids
• Use of activated charcoal if the patient presents soon after ingestion

In cases of severe overdose, admission to an intensive care unit may be necessary to provide advanced life support.

Prevention

Prevention of GHB overdose involves education on the risks associated with the drug's use, especially in recreational settings. It is also important to avoid mixing GHB with alcohol or other depressants. Individuals prescribed GHB for medical reasons should adhere strictly to their prescribed dosages.

See Also

• Drug overdose
• Substance abuse
• Poison control center

Resources

Latest articles - GHB overdose

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Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on GHB overdose for any updates.

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