GLS2

GLS2 is a gene that encodes for the enzyme glutaminase 2 in humans. This enzyme is primarily found in the liver and plays a crucial role in the metabolism of glutamine, one of the most abundant and versatile amino acids in the body.

Function

The GLS2 gene is responsible for the production of the glutaminase 2 enzyme. This enzyme catalyzes the conversion of glutamine to glutamate, a process that is essential for various metabolic pathways. Glutamate is a key molecule in cellular metabolism and is involved in processes such as protein synthesis, energy production, and the regulation of oxidative stress.

Clinical Significance

Alterations in the GLS2 gene have been associated with various health conditions. For instance, reduced expression of GLS2 has been observed in certain types of cancer, including hepatocellular carcinoma and breast cancer. This suggests that GLS2 may have a tumor suppressor function.

Moreover, studies have shown that GLS2 plays a role in the regulation of mitochondrial function and oxidative stress, which are critical processes in many diseases, including neurodegenerative diseases and cardiovascular diseases.

Research

Research on GLS2 is ongoing, with scientists aiming to better understand its functions and potential role in disease development and progression. This could potentially lead to the development of new therapeutic strategies targeting GLS2 for the treatment of various diseases.

File:GLS2 gene location on human chromosome 12.png

Location of the GLS2 gene on human chromosome 12.

See Also

• Glutaminase
• Glutamine
• Glutamate
• Metabolism
• Gene

External Links

• GLS2 at the National Center for Biotechnology Information (NCBI)

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