GRIK4

GRIK4 (Glutamate Ionotropic Receptor Kainate Type Subunit 4) is a protein that in humans is encoded by the GRIK4 gene. It is a subunit of the kainate receptor, which is a type of ionotropic glutamate receptor. Ionotropic glutamate receptors are central to the function of the nervous system, as they mediate most of the fast synaptic transmission in the central nervous system.

Function

The GRIK4 protein is a subunit of the kainate receptor, which is a type of ionotropic glutamate receptor. These receptors are named for their activation by the agonist kainic acid. The kainate receptor is involved in excitatory neurotransmission. The GRIK4 subunit is thought to control the calcium permeability of the receptor.

Clinical significance

Alterations in the GRIK4 gene have been associated with several psychiatric disorders, including bipolar disorder, schizophrenia, and major depressive disorder. In particular, a single nucleotide polymorphism (SNP) in the GRIK4 gene has been associated with a positive response to antidepressant treatment.

See also

• Glutamate receptor
• Kainate receptor
• Ionotropic glutamate receptor

References

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