Glycine receptor, alpha 1
Glycine receptor, alpha 1 (also known as GLRA1) is a protein that in humans is encoded by the GLRA1 gene. This protein is a subunit of the glycine receptor, which is a ligand-gated ion channel.
Function[edit]
The GLRA1 gene encodes the alpha 1 subunit of the glycine receptor. The glycine receptor is a member of the neurotransmitter gated ion channel protein family. It functions as a pentamer to form a ligand-gated ion channel. The binding of glycine to the receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of the neuron).
Clinical significance[edit]
Mutations in this gene cause some forms of hyperekplexia, a neurologic disorder characterized by startle response. The alpha 1 subunit is the primary binding site for the antagonist strychnine.
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