Gonadotropic hormone

Gonadorelin Acetate is a synthetic version of gonadotropin-releasing hormone (GnRH) used in the diagnosis and treatment of certain hormonal disorders. It is a decapeptide, meaning it is composed of ten amino acids. Gonadorelin Acetate is marketed under various brand names including Factrel, Lutrepulse and Kryptocur among others.

Medical Uses

Gonadorelin Acetate is used in the diagnosis of hypogonadism, a condition characterized by low sex hormone production. It is also used in the treatment of delayed puberty, infertility, and certain types of breast cancer.

Mechanism of Action

Gonadorelin Acetate works by stimulating the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These hormones are essential for normal growth, sexual development, and reproduction.

Side Effects

Common side effects of Gonadorelin Acetate include headache, nausea, and vomiting. More serious side effects may include allergic reactions, chest pain, and irregular heartbeat.

Pharmacokinetics

After administration, Gonadorelin Acetate is rapidly absorbed and distributed throughout the body. It is metabolized in the liver and excreted in the urine.

History

Gonadorelin Acetate was first synthesized in the 1970s. It was approved for medical use in the United States in 1978.

See Also

• Gonadotropin-releasing hormone
• Hypogonadism
• Luteinizing hormone
• Follicle-stimulating hormone

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