HLA-B57

HLA-B57 is a human leukocyte antigen serotype within HLA-B serotype group. The serotype is determined by the antibody recognition of antigen B*57. This broad antigen group also includes the more specific HLA-B*5701, B*5702, B*5703, and B*5704 antigens, among others. HLA-B57 is associated with slow progression to AIDS in HIV-infected individuals and a hypersensitivity reaction to the HIV medication abacavir.

Structure and Function

HLA-B57 is a part of the HLA-B series of proteins, which are integral to the immune system. These proteins are found on the surface of cells and play a crucial role in the immune system's recognition of foreign substances. HLA-B57, like other HLA proteins, is involved in presenting peptides from inside the cell to the immune system.

Clinical Significance

HLA-B57 has been found to be associated with a slower progression to AIDS in individuals infected with HIV. This is thought to be due to the ability of HLA-B57 to present a broader range of HIV peptides to the immune system, allowing for a more effective immune response.

In addition, HLA-B*5701, a specific antigen within the HLA-B57 group, is associated with a hypersensitivity reaction to the HIV medication abacavir. This reaction can be severe and life-threatening, and individuals with the HLA-B*5701 antigen are generally advised to avoid abacavir.

Testing and Treatment

Testing for the presence of HLA-B57 and specifically HLA-B*5701 is recommended for individuals who are HIV positive and considering treatment with abacavir. This can be done through a blood test.

If an individual tests positive for HLA-B*5701, alternative HIV medications should be considered to avoid the risk of a hypersensitivity reaction.

See Also

• Human leukocyte antigen
• AIDS
• Abacavir
• Immune system

References

‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian