HLA-B7

HLA-B7 is a human leukocyte antigen serotype within the HLA-B serotype group. The serotype is determined by the antibody recognition of antigen B*7. This broad antigen group also includes the more specific HLA-B*07:01, B*07:02, B*07:03, and B*07:04 antigens, among others. HLA-B7 is associated with certain medical conditions, including ankylosing spondylitis and Behcet's disease.

Structure and Function

HLA-B7 is a part of the HLA-B locus, which is a member of the major histocompatibility complex (MHC) class I molecules expressed on all nucleated cells. The primary function of these molecules is to display peptide fragments of non-self-proteins from within the cell to T cells; a cell displaying non-self-antigens is targeted for destruction.

Disease Associations

HLA-B7 has been associated with a number of autoimmune and infectious diseases. These include:

• Ankylosing spondylitis: HLA-B7 is one of the HLA-B27 subtypes strongly associated with ankylosing spondylitis.
• Behcet's disease: HLA-B7 has been implicated in Behcet's disease, a rare and chronic multisystem inflammatory disorder.

Distribution

HLA-B7 is found at highest frequencies in Western Europe, particularly in Spain, France, and the British Isles. It is also found at significant frequencies in North Africa, the Middle East, and among certain Native American populations.

File:HLA-B7 distribution.png

Distribution of HLA-B7.

See Also

• HLA-B
• Human leukocyte antigen
• Major histocompatibility complex
• Ankylosing spondylitis
• Behcet's disease

References

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