HPG80

hPG80 is a protein that is encoded by the gene C80 in humans. It is a member of the gastrin/cholecystokinin family of proteins, which are known to play a crucial role in various physiological processes, including cell growth, cell differentiation, and apoptosis.

Structure[edit | edit source]

The hPG80 protein is composed of 80 amino acids and has a molecular weight of approximately 10 kDa. It is characterized by a highly conserved sequence of seven amino acids, known as the gastrin/cholecystokinin motif, which is essential for its biological activity.

Function[edit | edit source]

hPG80 is primarily involved in the regulation of gastric acid secretion and gastric motility. It stimulates the release of gastric acid by binding to the CCK2 receptor on the surface of parietal cells in the stomach. In addition, it promotes gastric motility by acting on the smooth muscle cells of the stomach.

hPG80 also plays a role in cell growth and differentiation. It has been shown to stimulate the proliferation of various types of cells, including gastric mucosal cells and pancreatic cancer cells. Moreover, it promotes the differentiation of enteroendocrine cells, which are responsible for the production of various hormones in the gut.

Clinical significance[edit | edit source]

Abnormal expression of hPG80 has been associated with several types of cancer, including gastric cancer, pancreatic cancer, and colorectal cancer. It has been suggested that hPG80 may serve as a potential biomarker for these cancers.