ITGA2B
ITGA2B (Integrin Subunit Alpha 2b) is a protein that in humans is encoded by the ITGA2B gene. This protein is a part of the integrin family and is primarily expressed on platelets. It plays a crucial role in the process of platelet aggregation and is a receptor for fibrinogen, fibronectin, von Willebrand factor, and vitronectin.
Function[edit | edit source]
ITGA2B, along with ITGB3, forms a heterodimer known as glycoprotein IIb/IIIa (GPIIb/IIIa). This complex is the most abundant integrin present on the surface of platelets. It is responsible for platelet aggregation by acting as a receptor for fibrinogen and von Willebrand factor, which are both involved in the blood clotting process.
Clinical Significance[edit | edit source]
Mutations in the ITGA2B gene can lead to conditions such as Glanzmann's thrombasthenia, a rare disorder characterized by the inability of platelets to properly aggregate and form clots. This can result in prolonged bleeding times and an increased risk of hemorrhage.
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD