Integrator complex subunit 5

Integrator complex subunit 5 (INTS5) is a protein that in humans is encoded by the INTS5 gene. The protein is a part of the Integrator complex, a complex involved in the small nuclear RNA (snRNA) processing.

Function

The INTS5 protein is a component of the Integrator complex. This complex is known to be involved in the processing of small nuclear RNAs (snRNA). It associates with the C-terminal domain of RNA polymerase II large subunit. The complex is composed of at least 12 subunits, INTS1 to INTS11 and INTS13, and associates with RNA polymerase II.

Clinical significance

Alterations in the INTS5 gene have been associated with a variety of human diseases. For example, mutations in this gene have been linked to cancer, specifically in the progression of prostate cancer. Further research is needed to fully understand the role of INTS5 in disease progression and potential therapeutic applications.

See also

• Integrator complex
• RNA polymerase II
• Prostate cancer

External links

• Gene
• UniProt

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