KCNIP4

KCNIP4 is a gene that encodes the protein Kv channel interacting protein 4. This protein is a member of the Kv channel interacting protein (KChIP) family, which are calcium binding proteins that interact with Kv4 potassium channels to modulate their function.

Function

KCNIP4 is involved in the regulation of potassium channels, specifically the Kv4 family of channels. These channels are responsible for the A-type current in neurons, which is crucial for the regulation of action potentials. KCNIP4 interacts with these channels and modulates their function, affecting the electrical properties of the neuron.

Structure

The KCNIP4 protein has four N-terminal EF-hand domains, which are calcium-binding motifs. These domains allow the protein to bind to and modulate the function of Kv4 channels. The C-terminal region of the protein is responsible for its interaction with other proteins, such as DREAM and presenilin.

Clinical significance

Mutations in the KCNIP4 gene have been associated with various neurological disorders, including epilepsy and schizophrenia. In addition, altered expression of KCNIP4 has been observed in the brains of patients with Alzheimer's disease, suggesting a potential role in the pathogenesis of this disease.

See also

• Kv channel interacting protein
• Potassium channel
• EF-hand
• DREAM
• Presenilin

References

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