KLF4

KLF4 (Kruppel-like factor 4) is a transcription factor that plays a crucial role in regulating gene expression within cells. It is encoded by the KLF4 gene in humans.

Function

KLF4 is a member of the Kruppel-like factor family of transcription factors, which are characterized by a DNA-binding domain of three C2H2-type zinc fingers. KLF4 is involved in various cellular processes, including cell differentiation, cell growth, apoptosis, cell cycle regulation, and stem cell maintenance.

Role in Stem Cells

KLF4 is one of the four Yamanaka factors (along with Oct4, Sox2, and c-Myc), which are essential for inducing pluripotency in somatic cells. This process, known as cellular reprogramming, allows differentiated cells to revert to a stem cell-like state, capable of differentiating into any cell type in the body.

Role in Cancer

Abnormal expression of KLF4 has been associated with several types of cancer, including breast cancer, gastric cancer, and colorectal cancer. In some cases, KLF4 acts as a tumor suppressor, inhibiting tumor growth and progression. In other cases, it can promote tumor development and progression, acting as an oncogene.

Clinical Significance

Due to its role in cellular reprogramming and cancer, KLF4 is a potential target for cancer therapy and regenerative medicine. Further research is needed to fully understand the complex roles of KLF4 in health and disease.

File:KLF4.png

KLF4 protein structure

See Also

• Transcription factor
• Kruppel-like factors
• Yamanaka factors
• Cellular reprogramming
• Cancer

References

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