LPAR6

LPAR6 or Lysophosphatidic Acid Receptor 6 is a protein that in humans is encoded by the LPAR6 gene. It is a member of the G protein-coupled receptor family and plays a significant role in hair development.

Function

LPAR6 is a receptor for lysophosphatidic acid (LPA), a mediator of many cellular processes. It couples to the G protein G_i and inhibits adenylate cyclase activity. This receptor is predominantly expressed in the hair follicle and has been implicated in hair growth regulation.

Clinical significance

Mutations in the LPAR6 gene have been associated with hypotrichosis 7, a condition characterized by sparse hair growth. Studies have shown that LPAR6 is essential for the normal structure and function of the hair shaft, and mutations in this gene can lead to abnormalities in the hair follicle and shaft.

See also

• Lysophospholipid receptor
• Hypotrichosis

External links

• GeneCards: LPAR6

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