MED18
MED18 is a gene that encodes a component of the Mediator complex in humans. The Mediator complex is a multi-protein complex that functions as a transcriptional coactivator in all eukaryotes. It plays a key role in the regulation of RNA polymerase II-dependent gene transcription.
Function[edit | edit source]
MED18, also known as Mediator complex subunit 18, is a part of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. MED18 functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, and therefore MED18, is required for the transcription of most genes.
Structure[edit | edit source]
The MED18 gene is located on the chromosome 6 (6q23.3) and spans 15.54 kb. The gene includes 9 exons and encodes a 187-amino acid protein. The protein is a part of the Mediator complex, which is composed of 26 to 30 subunits and includes a head, middle, tail, and a kinase module.
Clinical significance[edit | edit source]
Mutations in the MED18 gene have been associated with various diseases. For example, a study found that MED18 is overexpressed in breast cancer tissues and can promote cell proliferation and tumor growth. Therefore, MED18 could potentially serve as a therapeutic target for breast cancer.
See also[edit | edit source]
References[edit | edit source]
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Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD